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Hydroxyurea segal j w et al 2008 hydroxyurea essay

Sickle Cell Low blood count, Ovid, Cresta, Cell

Research from Essay:

Hydroxyurea

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Segal, M. B., et al., (2008), Hydroxyurea intended for the Treatment of Sickle Cell Disease

Baltimore, MD: AHRQ

Variables/Key Concepts

To ascertain efficacy, performance, harms, and barriers in the use of hydroxyurea treatment of sickle cell disease for determining solutions and additional research require.

Sampling

Studies based on parameters.

Conducted by simply experts in sickle cellular disease management, clinical trial methodology, methodical review, epidemiological studies, and ethics and adherence exploration.

Instruments/Data Collection

Instruments had been quality analysis, data removal, and facts grading. Materials inclusion tailored toward research questions. Research on children and adults evaluated independently. Included randomized trials, non-randomized trials, cohort studies with control organizations, and pre/post studies. Reviews of data was based on variable-based research questions.

Results

Hydroxyurea lowered the pace of hospitizations among children with sickle cell disease and brought up HbF cell percentages.

Strengths/Limitations

Limited facts for degree of toxicity, barriers, and guide dosing. Insufficient data for effectiveness and safety.

Critique

Even with the use of professionals, there was zero appropriate style method described. Identifies exploration needs pertaining to toxicity, information dosing, efficiency, and protection.

Strouse, M. J., et al., (2008), Hydroxyurea for Sickle Cellular Disease: A Systematic Review to get Efficacy and Toxicity in Children, Pediatrics, 122: six. Doi: twelve. 1542/peds. 2008-0441

Retrieved coming from http://www.pediactricsdigest.mobi/content/122/6/1332.full

Variables/Key Concepts

A synthesized literature review for the efficacy, success, and toxicity of hydroxyurea in children.

Sampling

Picked randomized trial offers, observational studies, and case information that assessed the efficiency, and toxicity of hydroxyurea in kids with sickle cell disease.

Design/Method

Two reviewers shortcut data sequentially in analyze design, patient characteristics, and outcomes. Assessed study top quality independently.

Instruments/Data Collection

Musical instruments were sources, quality examination, data activity with detailed evidence tables, and evidence grading. Used studies of randomized handled trials, cohort studies with control groups, and pre/post studies.

Outcomes

Strong proof of increasing HbF and reducing hospitalization. Moderate evidence of lessening pain turmoil and support of increased risk of inversible cytopenias, and rash. Poor evidence for decreasing neurologic events. Range to referral center and need of frequent monitoring may be obstacles to use.

Strengths/Limitations

Limited predictors to response.

Critique

Simply no defined methodology. Good to evaluate for limitations to use of hydroxyurea as well as suggestions for further research in neurologic incidents and more data on minimizing pain measures.

Kavanagh, P. L., ainsi que al., (2011), Management of kids with Sickle Cell Disease: A

Thorough Review of Books, Pediatrics, 128: 6. Doi: 10. 1541/peds. 2010-3686

pp e1552-e1574, gathered from http://pediatrics.aappublications.org/content/1128/6/e1552.full.pdf+hml

Variables/Key Principles

Review the standard of literature to get preventative interventions and remedying of complications to facilitate the usage of evidence-based medication and need of additional research.

Sampling

Randomized cohort cases, handled studies, multiple time series studies, and uncontrolled research.

Design/Method

Identified data based upon relevant matters dated via January 95 to The spring 2010. Data was separately reviewed by two specialists.

Instruments/Data Collection

Instruments were common contact form, U. H. Preventative Support Task Power ratings, RCTs, and meta-analysis categorized. Separated studies depending on relevancy of 28 subject areas concerning Nationwide Institute of Health guidelines for the care of kids with sickle cell disease under three categories.

Results

Lack of

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